Cancer and Nano-Mechano Biology Laboratory (CNMB)
CURRENT RESEARCH AREAS
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Development of novel magnetic nanoparticles for biomechanical effect based cancer therapy |
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Mechano-biological aspects of cytoskeleton in internalization and metastasis |
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Magnetic nanoparticles incorporated hydrogels with tunable stiffness for tissue regeneration |
RESEARCH TEAM
PhD Scholars (Ongoing)
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LINSHINA T |
The study focuses on the synergistic effect of curcumin-coated magnetic (iron) nanoparticles to induce apoptosis of breast cancer cells (MCF-7 and MDA-MB-231) in the presence and absence of a static magnetic field. The cell-selective changes in mode of cell death and biomechanical aspects of cells are the key interests of the study. The important parameters analyzed include cell stiffness, traction forces, adhesion strength, cytoskeletal organization, and migration. The ultimate aim is to establish magneto-mechanical therapy as a potential strategy for targeted breast cancer treatment.
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M.Sc., M.A.
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The researcher aims to explore the distinct properties of multiple magnetic nanoparticles inside cervical cancer cell lines, particularly focusing on their internalization pathways in the cells. The insights from this research can potentially help develop techniques to augment existing diagnostic methods of cervical cancer detection. A comprehensive analysis of the therapeutic potential of these particles with respect to cervical cancer shall also be studied.
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The research focuses on the design of plant-based metal nanoparticles as senolytic agents. The potential of external mechanical forces to tune these nanoparticles, producing changes in substrate stiffness, consequently affecting cellular senescence, will be explored. Understanding the interplay between nanoparticle-mediated senolytic activity and mechanical stimulation may provide novel insights into ageing biology and lead to the development of innovative anti-ageing therapeutic approaches.
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RISHAD K A M.Sc.
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The research focuses on the development of biologically relevant molecules conjugated magnetic nanoparticles for targeted cancer therapy. Novel nanoparticles will be designed to enhance cellular internalization and tumor targeting. The effect of external magnetic fields on diagnostic and therapeutic aspects will be investigated through in vitro and in vivo studies using advanced imaging and molecular biology techniques.
